Events List

DateEvent TypeSpeaker
12/01/2023ArXiv DiscussionPopov [ + ]
12/01/2023Informal Astro TalkJames Sullivan [ + ]
12/04/2023CCPP Brown BagDavid Hogg [ + ]
12/04/2023HEP Discussion SessionsZare [ + ]
12/04/2023Informal Astro TalkJonathan Morag [ + ]
12/05/2023Astro SeminarLuca Comisso [ + ]
12/06/2023HEP SeminarCarlos Wagner [ + ]
12/06/2023CCPP Pheno Journal Club [ + ]
12/07/2023Physics Dept ColloquiumWilliam Jacobs [ -- ]

Title: Rational Design of Multicomponent Biomolecular Condensates
Abstract: Biology provides numerous examples of phase-separated protein andnucleic acid condensates, which establish distinct compartments forspatially organizing biomolecules within living cells. This mechanismof spatial organization relies on the ability of biomolecular systemsto produce complex phase diagrams by tuning the interactions amongmolecules in a multicomponent mixture. To reproduce this behavior insynthetic systems, it is essential that we identify design rules thatmap the sequences of individual biomolecules to the emergent phasebehavior of multicomponent systems. In this talk, I will describerecent theoretical and computational advances towards the goal ofdesigning fully programmable, synthetic multiphase condensates. Theseresults take the form of scaling relations that bound the complexityof phase diagrams that can be achieved in various biomolecularsystems, as well as optimization algorithms for designing biomolecularmixtures that can spontaneously assemble into prescribed multiphasecondensates. I will also discuss how nucleation pathways forbiomolecular condensate assembly can be rationally designed, providinga mechanism for achieving precise spatiotemporal control ofmulticomponent, multiphase systems. Taken together, these designrules provide a deeper understanding of the limits ofphase-separation-mediated spatial organization in biological systemsand establish practical strategies for engineering fully programmablemultiphase condensates. (4:00 PM - 5:30 PM, 726 Broadway, 940, CCPP Seminar)
12/08/2023ArXiv DiscussionPopov [ + ]
12/11/2023HEP Discussion SessionsZare [ + ]
12/13/2023HEP SeminarLianTao Wang [ + ]
12/14/2023Physics Dept ColloquiumJo Dunkley [ + ]
12/15/2023ArXiv DiscussionPopov [ + ]
12/15/2023Informal HEP TalkRaphael Bousso [ + ]
12/15/2023NYU Physics Holiday Party [ + ]
12/18/2023HEP Discussion SessionsZare [ + ]
12/25/2023Holiday [ + ]
12/26/2023Holiday [ + ]
12/27/2023Holiday [ + ]
12/28/2023Holiday [ + ]
12/29/2023Holiday [ + ]