| Abstract: Diffusing light can be used to quantitatively probe physiology of tissues located far below body surfaces. The emerging light fields contain a wealth of diagnostic information about blood flow, blood oxygenation, and oxygen metabolism, about molecular biomarkers such as cytochrome-C oxidase, lipid, and water, and about health biometrics such as intracranial pressure and cerebral autoregulation. I will introduce the essential diffuse optics measurement tools and paradigms, many of which were hatched in the physics and bioengineering communities. Then I will discuss selected clinical and pre-clinical examples, mostly related to brain, that we have investigated with our collaborators at the Hospital of the University of Pennsylvania. |